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Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases
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Home Page > Health > Cancer > Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases
Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases
Posted: Oct 28, 2010 |Comments: 0
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Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases
By: Montwrobleski77
About the Author
Monty Wrobleski is the author of this article. For more information please click on the following links
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Article Source: http://www.articlesbase.com/ – Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases
Another interesting study is called, “The case for routine cervical mediastinoscopy prior to radical surgery for malignant pleural Mesothelioma” by J.E. Pillinga, D.J. Stewarta, A.E. Martin-Ucara, S. Mullerb, K.J. O’Byrnec, D.A. Wallera – Eur J Cardiothorac Surg 2004;25:497-501. Here is an excerpt: “Objectives: To assess whether cervical mediastinoscopy is necessary before radical resection of malignant pleural mesothelioma (MPM). Methods: Patients who underwent radical excision of MPM in a 48-month period were prospectively followed for evidence of disease recurrence and death. Histological evidence of extra pleural lymph node metastases was correlated with survival. Lymph node size at intraoperative lymphadenectomy was correlated with the presence of metastatic tumour. Results: The 55 patients who underwent radical resection (51 extra pleural pneumonectomies and 4 radical pleurectomies) comprised 50 men and 5 women with a median age of 58 years, range 41–70. Histological examination revealed 50 epithelioid, four biphasic and one sarcomatoid histology. Postoperative IMIG T stage was stage I 4, II 11, III 30 and IV 10. Postoperatively the 17 patients with metastases to the extra pleural lymph nodes had significantly shorter survival (median 4.4 months, 95% CI 3.2–5.4) than those without (median survival 16.3 months, 95% CI 11.6–21.0) P=0.012 Kaplan–Meier analysis. Seventy-seven extra pleural lymph nodes without metastases were measured with a mean long axis diameter of 16.9 mm (range 4–55); 22 positive nodes had a mean long axis diameter of 15.2 mm (range 6–30). In 15 of the 17 patients with positive extra pleural nodes, the nodes could have been biopsied at cervical mediastinoscopy. Conclusions: This study confirms that extra pleural nodal metastases are related to poor survival. Pathological nodal involvement cannot be predicted from nodal dimensions. These data suggest that all patients being considered for radical resection of MPM should preferentially undergo preoperative cervical mediastinoscopy irrespective of radiological findings.”
Another interesting study is called, “Induction chemotherapy, extrapleural pneumonectomy, and radiotherapy in the treatment of malignant pleural mesothelioma: The Memorial Sloan-Kettering experience” – Volume 49, Supplement 1, Pages S71-S74 (July 2005) by Raja M. Flores. Here is an excerpt: “Summary – Approximately 25% of patients with malignant pleural mesothelioma (MPM) prove unresectable at surgery and the median survival of stage III MPM is <12 months even after complete resection by extrapleural pneumonectomy. From 1939–2004, a series of sequential clinical trials has been performed at our institution. The surgical procedure has been modified and improved upon, and adjuvant hemithoracic radiation (RT) standardized. The evolution of our current standard of care for MPM is discussed. Improving chemotherapy for MPM led us to test induction chemotherapy followed by EPP and adjuvant RT for locally advanced MPM to assess feasibility. Patients with T3–4 or N2 MPM by CT and PET scans were enrolled on a phase II study. Induction therapy was: gemcitabine (1250mg/m2days 1, 
and cisplatin (75mg/m2day 8)×2–4 cycles. Patients underwent EPP 3–5 weeks after induction therapy, then 54 Gy RT 4–6 weeks postop. At surgery, 8/9 had complete resection by EPP with no postoperative deaths. All received planned adjuvant RT. This combined modality approach is feasible for locally advanced MPM, and initial analysis suggests improved resectability. This experience supports additional studies of induction and multimodality therapy, especially with regimens such as cisplatin and pemetrexed which may be better tolerated and more effective.”
Another interesting study is called, “EGFR overexpression in malignant pleural mesothelioma: An immunohistochemical and molecular study with clinico-pathological correlations” by Destroa, G.L. Ceresolib, M. Fallenic, P.A. Zucalib, E. Morenghid, P. Bianchia, C. Pellegrinic, N. Cordanic, V. Vairac, M. Alloisioe, A. Rizzif, S. Bosaric, M. Roncallig – Volume 51, Issue 2, Pages 207-215 (February 2006). Here is an excerpt: “Summary – The epidermal growth factor receptor (EGFR) is overexpressed in many epithelial malignancies, against which some antitumoral drugs have been developed. There is a lack of information as to EGFR expression in malignant pleural mesothelioma (MPM), an aggressive and fatal cancer poorly responsive to current oncological treatments. Our aim was to: (a) compare EGFR immunohistochemical expression with mRNA levels measured by real time PCR; (b) assess the relationships between EGFR expression and clinico-pathological data including survival; (c) analyze the EGFR mutations.
We developed an immunohistochemical method of EGFR evaluation based on the number of immunoreactive cells and staining intensity in 61 MPMs. EGFR immunoreactivity was documented in 34/61 (55.7%) cases. A significant correlation between EGFR protein and mRNA levels (p=0.0077) was found, demonstrating the reliability of our quantification method of EGFR membrane expression. Radically resected patients (p=0.005) and those with epithelial histotype (p=0.048) showed an increased survival. No statistical correlation between EGFR immunoreactivity and patients survival was observed. No EGFR mutation was documented.
This study documents EGFR overexpression in MPM at the protein and the transcriptional levels; it proposes a reliable method for EGFR expression evaluation in MPM. EGFR levels are not associated with clinico-pathological features of patients, including survival.”
We all owe a debt of gratitude to these fine researchers. If you found any of these excerpts interesting, please read the studies in their entirety.
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Maurice Lucas Succumbs to Most cancers
Posted: Nov 07, 2010 |Comments: 0
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Maurice Lucas Succumbs to Most cancers
By: Nolan Bray
About the Author
Digital Age Marketing Group, Inc. is a full service internet marketing firm that prides itself on unparalleled service and performance. We are committed to providing unbiased internet marketing advice and prudent strategies for growing your business. Our services are always tailored to your unique needs. We provide SEO optimization, sales lead generation, and Google local business center ad placement. Digital Age Marketing Group’s search engine visibility is geared towards driving potential clie
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Article Source: http://www.articlesbase.com/ – Maurice Lucas Succumbs to Most cancers
Maurice Lucas – who was fighting in opposition to bladder most cancers for a prolonged time died in his homeland on Sunday. Maurice was 58 many years previous, and acquired played some fantastic hoop video games and dazzled numerous. He helped Portland to carry home an NBA title in 1977 as a power ahead and he was also the assistant coach for the Trailblazers. Lucas has three children, two sons – David and Maurice II and a daughter Kristin, who are now left alone with their mother – Pamela.
Lucas acquired a Gratifying Profession
Ahead of leaving the group to undertake surgical treatment final 12 months, Maurice was serving as an assistant coach to the Portland Trailblazers. He joined the crew in Portland in 1976, and played 14 professional seasons following that. Maurice had a nutritious and satisfying profession, but ‘the Enforcer’ will absolutely be missed by his group and his former teammates.
Taking walks Across the Road Carries Dangers Too
Cancer has been the purpose for the deaths of millions close to the globe. Another form of cancer malignancy that influences men and women who work in and all-around asbestos is Mesothelioma. Mesothelioma causes degradation of the mesothelium, and thus it has an effect on all of a human’s inner organs. Mesothelioma has been close to given that the time of the Commercial Revolution considering that that was the explanation for the unfold of this sickness. Hundreds of factories and industries that have been set up because the Commercial Revolution nonetheless continue to operate, but with rigid protocols, despite the danger of asbestos. Asbestos is not the only hazardous product or service in industry, as long as the security measures are followed, there will not be any well being dangers. With that said, there has been an improve in the fee of this variety of most cancers in Europe.
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Don’t touch that Asbestos!
Don’t touch that Asbestos!
Don’t touch that Asbestos!
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Home Page > Home Improvement > Construction > Don’t touch that Asbestos!
Don’t touch that Asbestos!
Posted: Oct 15, 2010 |Comments: 0
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Don’t touch that Asbestos!
By: Rico Valdez
About the Author
Rico Valdez – Associated Writer for Abbas & Company Inc.Ottawa Home Renovations
(ArticlesBase SC #3478830)
Article Source: http://www.articlesbase.com/ – Don’t touch that Asbestos!
Asbestos has always been connected to mesothelioma, a rare but deadly cancer that spurs the development of tumors on linings surrounding vital organs. Asbestos, is not used in construction these days, but is still known to be contained within numerous old structures, among them schools and older factories. In its undisturbed state Asbestos is harmless but once disturbed the fibers are released into the air and become very dangerous, this is normally caused by construction or fires/earthquakes.
If you think that your property has asbestos its best to remove it. The asbestos removal process is quite lengthy and complicated. All precautions must be made to remove any possibility of asbestos fibers being released into the air.If such an event would occur, the asbestos fibers would put everyone in the immediate vicinity in danger of contracting mesothelioma. These microscopic fibers are too tiny to detect and do not have any smell or taste nor can you see them. The dangers that the removal process entails have recently been subject to controversy. Many believe that simply leaving it alone is the best solution because removing it might disturb it thus cause problems.
Many individuals, companies, and governments have already taken the initiative to remove asbestos from older buildings. Despite the dangers many older structures have undergone asbestos removal.Many have contractors remove the asbestos. It is not like the controversy over the removal process will be done anytime soon.By understanding the dangerous risks involved with removing asbestos will help many make the right choice. At the end of the day, whether or not the owner removes or does not remove the asbestos lies within their understanding. While this decision is not always straight-forward, it is important that one makes an informed move.
While many feel the dangers of Asbestos removal far outweigh the benefits of keeping it undisturbed, the very thought of a highly dangerous compound in the structure can make many uneasy. So for many it just may be fear driving them to act or the fear of future harm. Therefore putting many, including the construction workers, in much danger.So once again, please consult a highly trained professional and educate yourself prior to insisting on removing your asbestos.
Retrieved from “http://www.articlesbase.com/construction-articles/dont-touch-that-asbestos-3478830.html”
(ArticlesBase SC #3478830)
Rico Valdez -
About the Author:
Rico Valdez – Associated Writer for Abbas & Company Inc.Ottawa Home Renovations
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Source: http://www.articlesbase.com/construction-articles/dont-touch-that-asbestos-3478830.html
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rico valdez associated writer for abbas company inc ottawa home renovations
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